1. Grollman, A.P. and Lehninger, A.L.  Enzymatic synthesis of L-ascorbic acid in different animal species.  Arch. Biochem. Biophys. 69, 458-467 (1957).

2. Bublitz, C., Grollman, A.P., and Lehninger, A.L.  The enzymatic conversion of D-glucuronate to L-ascorbate and L-xylulose in animal tissues. Biochem. Biophys. Acta 27, 221-222 (1958).

3. Grollman, A.P. and Gamble, J.L.  Metabolic alkalosis, a specific effect of adrenocortical hormones.  Am. J. Physiol. 196, 135-140 (1959).

4. York, J.L., Grollman, A.P. and Bublitz, C.  TPN-L-gulonate dehydrogenase. Biochem. Biophys. Acta 47, 298-306 (1961).

5. Grollman, A.P., Harrison, H.C., and Harrison, H.E.  The renal excretion of citrate.  J. Clin. Invest. 40, 1290-1296 (1961).

6. Grollman, A.P. and Odell, G.B.  The removal of bilirubin by albumin binding during peritoneal dialysis.  New Eng. J. Med. 267, 279-282 (1962).

7. Grollman, A.P. and Odell, G.B.  Site of reabsorption of citrate and calcium in the renal tubule of the dog.  Am. J. Physiol. 205, 697-701 (1963).

8. Summers, D., Grollman, A.P., and Hasenclever, H.F.  Polysaccharaide antigens of candida cell wall.  J. Immunology 92, 491-499 (1964).

9. Grollman, A.P. and Osborn, M.J.  O-phosphorylethanolamine:  a component of lipopolysaccharide in certain gram-negative bacteria. Biochemistry 3, 1571-1574 (1964).

10. Grollman, A.P., Hall, C.W., and Ginsburg, V.  Biosynthesis of fucosyllactose and other oligosaccharides found in milk.  J. Biol. Chem. 240, 975-981 (1965).

11. Grollman, A.P.  GDP-L-fucose:  lactose fucosyltransferase from mammary gland.  In:  Methods in Enzymology VIII, Complex Carbohydrates.  Neufield, E.F. and Ginsburg, V. (Eds.), Academic Press, NY, pp. 351-353 (1965).

12. Marcus, D.M. and Grollman, A.P.  Studies of blood group substances I.  Caprine precipitating antisera to human Le^a and Le^b blood group substances.  J. Immunology 97, 867-875 (1966).

13. Grollman, A.P. and Marcus, D.M.  Enzymatic incorporation of fucose in blood group H substance.  Biochem. Biophys. Res. Commun. 25, 542-548 (1966).

14. Grollman, A.P.  Structural basis for inhibition of protein biosynthesis by emetine and cycloheximide based on an analogy between ipecac alkaloids and glutarmide antibiotics.  Proc. Natl. Acad. Sci. USA 56, 1867-1875 (1966).

15. Marcus, D.M., Bastani, A.M., Rosenfield, R.E. and Grollman, A.P.  Studies of blood group substances II.  Hemaglutinating properties of caprine antisera to human Le^a and Le^b blood group substances.  Transfusion 7, 277-280 (1967).

16. Grollman, A.P.  Metabolic pathways leading to the biosynthesis of blood group substances.  In:  Hartford Foundation Symposium on Blood Groups.  Kuhns, W.J. (Ed.), Better Bellevue Association, NY, pp. 33-46 (1967).

17. Grollman, A.P.  Mode of action of antisomycin.  J. Biol. Chem. 242, 3326-3233 (1967).

18. Grollman, A.P.  Structural basis for the inhibition of protein biosynthesis:  Mode of action of tubulosine.  Science 157, 84-85 (1967).

19. Rao, S.S. and Grollman, A.P.  Cycloheximide resistance in yeast:  A property of the 60s ribosomal subunit.  Biochem. Biophys. Res. Commun. 29, 696-704 (1967).

20. Grollman, A.P.  Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells.  J. Biol. Chem. 243, 4089-4094 (1968).

21. Grollman, A.P. and Stewart, M.L.  Inhibition of the attachment of messenger ribonucleic acid to ribosomes.  Proc. Natl. Acad. Sci. USA 61, 719-725 (1968).

22. Grollman, A.P.  A proposed mechanism for the design of novel antiviral agents.  In:  Antimicrobial Agents and Chemotherapy-1968, 3640 (1969).

23. Horwitz, S.B. and Grollman, A.P.  Interactions of small molecules with nucleic acids. I.  Mode of action of anthramycin.  In: Antimicrobial Agents and Chemotherapy-1968, 21-24 (1969).

24. Grollman, A.P.  Rational design of chemotherapeutic agents.  In:  Annual Reports in Medicinal Chemistry-1968.  Cain, C.K. (Ed.), Academic Press, pp. 218-229 (1969).

25. Grollman, A.P.  Emetine:  New uses for an old drug.  The Ohio State Medical Journal 66, 257-259 (1970).

26. Jarkovsky, Z., Marcus, D.M. and Grollman, A.P.  A Fucosyltransferase found in human milk:  The product of the Lewis blood group gene. Biochemistry 9, 1123-1128 (1970).

27. Grollman, A.P.  Inhibition of protein biosynthesis:  Its significance in drug design.  In:  Molecular Pharmacology Vol. II, Drug Design.  Ariens, E.F. (Ed.), Academic Press, pp. 231-249 (1971).

28. Grollmaln, A.P. and Horwitz, S.B.  Rational design of antiviral agents.  In:  Molecular Pharmacology Vol. II, Drug Design. Ariens, E.F. (Ed.), Academic Press, pp. 261-276 (1971).

29. Stewart, M.L., Grollman, A.P., and Huang, M.T.  Aurintricarboxylic acid:  inhibitor of protein synthesis.  Proc. Natl. Acad. Sci. USA 68, 97-101 (1971).

30. Horwitz, S.B., Chang, S.C., Grollman, A.P., and Borkovec, A.B.  Chemosterilant action of anthramycin:  A proposed mechanism.  Science 174, 159-161 (1971).

31. Horwitz, S.B., Chang, C., and Grollman, A.P.  Studies on camptothecin I.  Effects on nucleic acid and protein synthesis.  Molecular Pharmacology 7, 632-644 (1971).

32. Grollman, A.P., Rosen, S. and Hite, G.  Potential inhibitors of protein biosynthesis.  J. Med. Chem. 14, 885-887 (1971).

33. Huang, M.T. and Grollman, A.P.  Effect of aurintricarboxylic acid on ribosomes and the synthesis of globin in rabbit reticulocytes. Molecular Pharmacology 8, 111-127 (1972).

34. Horwitz, S.B., Chang, C., and Grollman, A.P.  Antiviral action of camptothecin.  Antimicrobial Agents and Chemotherapy 2, 395-401 (1972).

35. Huang, M.T. and Grollman, A.P.  Mode of action of tylocrebine:  Effects of protein and nucleic acid synthesis.  Molecular Pharmacology 8, 538-550 (1972).

36. Brewer, C.F., Sternlicht, H., Marcus, D.M. and Grollman, A.P.  Binding of ¹³C-enriched methyl-D-glucopyranoside to concanavalin A as studied by carbon magnetic resonance.  Proc. Natl. Acad. Sci. USA 70, 1007-1011 (1973).

37. Brewer, C.F., Marcus, D.M., Sternlicht, H. and Grollman, A.P.  Binding of orientations of alpha and beta methyl-D-gluopyraniside to concanavailin A as studied by ¹³-carbon magnetic resonance.  Ann. NY Acad. Sci. 22, 978-988 (1973).

38. Grollman, A.P., Brewer, C.F., Sternlicht, H., and Marcus, D.M.  Interactions of saccharides with concanavalin A. II.  Mechanism of binding of alpha and beta-methyl-D-glucopyranoside to concanavalin A as determined by carbon magnetic resonance.  Biochemistry 12, 4448-4457 (1973).

39. Grollman, A.P. and Huang, M.T.  Inhibitors of protein synthesis in eukaryotes:  tools in cell research.  Symposium on Mechanisms of Antibiotic Action.  Federation Proceedings 32, 1673-1678 (1973).

40. Entner, N. and Grollman, A.P.  Inhibitors of protein synthesis:  a mechanism of amebicide action of emetine and other structurally-related compounds.  J. Protozool. 20, 160-163 (1973).

41. Huang, M.T. and Grollman, A.P.  Pyrocatechol violet:  An inhibitor of initiation of protein synthesis.  Biochem. Biophys. Res. Commun. 53, 1049-1059 (1973).

42. Brewer, C.F., Sternlicht, H., Marcus, D.M., and Grollman, A.P.  Carbon-13 magnetic resonance studies of carbohydrate interactions with concanavalin A.  Biology and Medicine, May 9-11, 1973 at Argonne, Illinois, sponsored by the US Atomic Energy Commission.

43. Brewer, C.F., Sternlicht, H., Marcus, D.M. and Grollman, A.P.  Interaction of saccharides with concanavalin A. III.  Relation between calcium ions and the binding of saccharides to concanavalin A.  J. Biol. Chem. 259, 4614-4616 (1974).

44. Liao, L.L., Horwitz, S.B. and Grollman, A.P.  Gallin (9-(2’-carboxyphenyl)-3,4,5,6l-tetrahydroxyxanthene), a new inhibitor of Escherichia coli ribonucleic acid polymerase. Biochemistry 13, 1331-1337 (1974).

45. Takeshita, M., Horwitz, S.B. and Grollman, A.P.  Bleomycin, an inhibitor of vaccinia virus replication.  Virology 60, 455-465 (1974).

46. Grollman, A.P., Grunfeld, C., Brewer, C.F. and Marcus, D.M.  Molecular pharmacology of plant lectins:  studies on ricin and concanavalin A.  Cancer Chemotherapy Reports 58, 491-501 (1974).

47. Grunfield, C., Grollman, A.P. and Rosen, O.M.  Structure activity relationship of adrenergic compounds on the adenylate cyclase of frog erythrocytes. Molecular Pharmacology 10, 605-614 (1974).

48. Grollman, A.P. and Jarkovsky, Z.  Emetine and related alkaloids.  In: Antibiotics:  Mode of Action, Vol. III, 420-435 (1975).

49. Liao, L.L., Horwitz, S.B., Steward, D., Martin, J., Huang, M.T. and Grollman, A.P.  Triphenylmethane dyes as inhibitors of reverse transcriptase, RNA polymerase, and protein synthesis:  Structure activity relationships. J. Med. Chem. 18, 117-120 (1975).

50. Pesando, J.M. and Grollman, A.P.  Proton magnetic resonance studies of carbonic anhydrase III.  Binding of sulfonamides.  Biochemistry 14, 689-693 (1975).

51. Takeshita, M., Grollman, A.P., and Horwitz, S.B.  Effect of ATP and other nucleotides on the bleomycin-induced degradation of vaccinia virus DNA.  Virology 69, 453-463 (1976).

52. Liao, L.L., Grollman, A.P., and Horwitz, S.B.  Mechanism of action of the 12,13-epoxytrichothecene, anguidine, an inhibitor of protein synthesis. Biochimica et Biophysica Acta 454, 273-284 (1976).

53. Takeshita, M., Horwitz, S.B. and Grollman, A.P.  Mechanism of the antiviral action of bleomycin.  Ann. NY Acad. Sci. 284, 367-374 (1977).

54. Chien, M., Grollman, A.P. and Horwitz, S.B.  Bleomycin-induced interactions:  fluorescence and proton magnetic resonance studies.  Biochemistry 16, 3641-3647 (1977).

55. Hatayma, T., Goldberg, I., Takeshita, M. and Grollman, A.P.  Nucleotide specificity in DNA scission by neocarzinostatin.  Proc. Natl. Acad. Sci. USA 75, 3603-3607 (1978).

56. Takeshita, M., Grollman, A.P., Ohtsubo, E., and Ohtsubo, H.  Interactions of bleomycin with DNA.  Proc. Natl. Acad. Sci. USA 75, 5983-5987 (1978).

57. Takeshita, M. and Grollman, A.P.  A molecular basis for the interaction of bleomycin with DNA.  In:  Bleomycin, Chemical, Biochemical and Biological Aspects.  Hecht, S. (Ed.), Springer Verlag, NY, pp. 207-221 (1979).

58. Grollman, A.P. and Takeshita, M.  Interactions of bleomycin with DNA.  In: Advances in Enzyme Regulation. Vol. 18, Weber, G (Ed.), pp. 67-68 (1980).

59. Giloni, L., Takeshita, M., Johnson, F., Iden, C. and Grollman, A.P.  Bleomycin-induced strand scission of DNA:  Mechanism of deoxyribose cleavage.  J. Biol. Chem. 256, 8606-8615 (1981).

60. Lin, S.Y. and Grollman, A.P.  Interaction of bleomycin with deoxyribodinucleotides:  An NMR study.  Biochemistry 20, 7589-7598 (1981).

61. Takeshita, M., Kappen, L., Grollman, A.P. and Goldberg, I.  Strand-scission of DNA by neocarzinostatin, auromomycin, and bleomycin:  Studies on base release and sequence specificity.  Biochemistry 20, 7599-7606 (1981).

62. Lin, S.Y., Takeshita, M. and Grollman, A.P.  Bleomycin-DNA complex.  A proposed model.  In:  Biomolecular Stereodynamics.  Sarma, R.H. (Ed.), Adenine Press, Vol. 2, pp. 401-408 (1981).

63. Johnson, F., Pillai, K.M.R., Grollman, A.P., Tseng, L. and Takeshita, M.  Synthesis and biological activities of a new class of cytotoxic agents:  N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines.  J. Med. Chem. 27, 954-958 (1984).

64. Grollman, A.P., Takeshita, M., Pillai, K.M.R. and Johnson, F.  Origin and cytotoxic base properties of propenals derived from DNA.  Cancer Res. 45, 1127-1131 (1985).

65. Johnson, F and Grollman, A.P.  Cytotoxic base propenals from DNA.  In:  Cancer Chemotherapy Experimental and Clinical Progress, Martinus Nijhoff Publishers, Boston (1985).

66. Grollman, A.P., Johnson, F., Pillai, K.M.R. and Takeshita, M.  Cytotoxic base propenals and the action of bleomycin.  In:  Molecular Basis of Cancer Part B:  Macromolecular Recognition, Chemotherapy, and Immunology.  Alan R. Liss, Inc., pp. 235-242 (1985).

67. Takeshita, M., Van der Keyl, H. and Grollman, A.P. Carcinogen induced insertion mutations in E. coli.  In:  Molecular Basis of Cancer, Part A:  Macromolecular Structure, Carcinogenesis and Oncogenes.  Alan R. Liss, Inc. pp. 389-399 (1985).

68. Shaikh, I.A., Johnson, F. and Grollman, A.P. Streptonigrin I. Structure-activity relationships among simple bicyclic analogues.  Rate dependence of DNA degradation of quinone reduction potential. J. Med. Chem. 29, 1329-1340 (1986).

69. Takeshita, M., Chang, C.-N., Johnson, F., Will, S.G. and Grollman, A.P.  Oligodeoxynucleotides containing synthetic abasic sites:  Model substrates for DNA polymerases and AP endonucleases.  J. Biol. Chem. 262, 10171-10179 (1987).

70. Kalnick, M., Chang, C.-N., Grollman, A.P., and Patel, D.J.  NMR studies of abasic sites in DNA duplexes.  Deoxyadenosine stacks into the helix opposite the cyclic analog of 2-deoxyribose.  Biochemistry 27, 924-931 (1988).

71. Moriya, M., Takeshita, M., Johnson, F., Peden, K., Will, S. and Grollman, A.P.  Targeted mutations induced by a single acetylaminofluorene DNA adduct in mammalian cells and bacteria.  Proc. Natl. Acad. Sci. USA 85, 1586-1589 (1988).

72. Grollman, A.P.  Base propenals and the toxicity of bleomycin.  In:  Organ Directed Toxicities of Anticancer Drugs.  Hacker, M.P., Lazo, J.S. and Tritton, T.R. (Eds.), Martinus Nijhoff Publishers, pp. 79-90 (1988).

73. Moriya, M., Takeshita, M., Peden, K. and Grollman, A.P.  Experimental system for the study of site-specific mutagenesis in mammalian cells and bacteria.  In:  DNA Replication and Mutagenesis.  Moses, R.E .and Summers, W.C. (Eds.), pp. 410-415 (1988).

74. Sanderson, J.S., Chang, C.-N., Grollman, A.P. and Henner, W.D.  Mechanism of DNA cleavage and substrate recognition by a bovine apurinic endonuclease. Biochemistry 28, 3894-3901 (1989).

75. Kalnick, M.W., Chang, C.-N., Johnson, F., Grollman, A.P. and Patel, D.J. NMR studies of abasic sites in DNA duplexes:  Deoxyadenosine stacks into the helix opposite acyclic lesions.  Biochemistry 28, 3373-3383 (1989).

76. Vesanver, G., Chang, C.-N., Eisenberg, M.E., Grollman, A.P. and Breslauer, K.J.  The influence of abasic and anucleosidic sites on the stability, conformation, and melting behavior of a DNA duplex:  Correlations of thermodynamic and structural data.  Proc. Natl. Acad. Sci. USA 86, 3614-3618 (1989).

77. Kouchakdjian, M., Marinelli, E., Gao, X., Johnson, F., Grollman, A.P. and Patel, D.J.  NMR studies of exocyclic 1,N²-propanodeoxyguanosine adducts (X) opposite purines in DNA duplexes:  Protonated X(syn).G(anti) pairing (neutral pH) at the lesion site.  Biochemistry 28, 5647-5657 (1989).

78. Grollman, A.P.  Site specific mutagenesis.  In:  Fifth International Conference on Environmental Mutagens.  Mendelsohn, M.L. (Ed.), Alan R. Liss, NY (1990).

79. Kouchakdjian, M., Eisenberg, M., Live, D., Marinelli, E., Grollman, A.P. and Patel, D.J.  NMR studies of an exocyclic 1,N²-propanodeoxyguanosine adduct (X) located opposite deoxyadenosine (A) in DNA duplexes at basic pH:  Simultaneous partial intercalation of X and A between stacked bases.  Biochemistry 29, 4456-4465 (1990).

80. Shibutani, S., Takeshita, M. and Grollman, A.P.  Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349, 431-434 (1991).

81. Kouchakdjian, M., Bodepudi, V., Shibutani, S., Eisenberg, M., Johnson, F., Grollman, A.P., and Patel, D.J.  NMR structural studies of the ionizing radiation adduct 8-oxodeoxyguanosine (8-oxodG) opposite deoxyadenosine in a DNA duplex.  8-OxodG(syn):dA(anti) alignment at lesion site.  Biochemistry 30, 1403-1412 (1991).

82. Kouchakdjian, M., Eisenberg, M., Johnson, F., Grollman, A.P., and Patel, D.J. Structural features of an exoyclic adduct positioned opposite an abasic site in a DNA duplex.  Biochemistry 30, 3262-3270 (1991).

83. Shibutani, S., Gentles, R., Johnson, F. and Grollman, A.P.  Isolation and characterization of oligodeoxynucleotides containing dG-N²-AAF and oxidation products of dG-C8-AF.  Carcinogenesis 12, 813-818 (1991).

84. Moriya, M., Ou, C., Bodepudi, V., Johnson, F., Takeshita, M. and Grollman, A.P.  Site-specific mutagenesis using a gapped duplex vector:  A study of in vivo translesion synthesis past 8-oxodeoxyguanine. Mutation Res. 254, 281-288 (1991).

85. Tchou, J., Kasai, H., Shibutani, S., Chung, M.H., Laval, J., Grollman, A.P., and Nishimura, S.  8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.  Proc. Natl. Acade. Sci. USA 88, 4690-4694 (1991).

86. Grollman, A.P.  Mitomycin and bleomycin.  In:  Japanese  Journal of Cancer Res. 82, Elsevier Science Publishers (1991).

87. Kalman, T.I., Marinelli, E.R., Xu, B., Benugopala Reddy, A.R., Johnson, F. and Grollman, A.P.  Inhibition of cellular thymidylate synthesis by cytotoxic propenal derivatives of pyrimidine bases and deoxynucleosides. Biochemical Pharmacology 42, 432-437 (1991).

88. Grollman, A.P.  Structural basis for the mutagenic specificity of 8-oxoguanine-DNA.  In:  Proceedings of the Seventh Conversation in Biomolecular Stereodynamics.  Sarma, R. (Ed.), Adenine Press (1992).

89. Michaels, M.L., Cruz, C., Grollman, A.P. and Miller, J.H.  Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.  Proc. Natl. Acad. Sci. USA 89, 7022-7025 (1992).

90. Michaels, M.L., Tchou, J., Grollman, A.P. and Miller, J.H.  A repair system for 8-oxo-7,8-dihydrodeoxyguanine (8-hydroxyguanine).  Biochemistry 31, 10964-10968 (1992).

91. Plum, G.E., Grollman, A.P., Johnson, F. and Breslauer, K.J.  Influence of an exocyclic guanine adduct on the thermal stability, conformation, and melting thermodynamics of a DNA duplex.  Biochemistry 31, 12096-12102 (1992).

92. Shibutani, S., Bodepudi, V., Johnson, F. and Grollman, A.P.  Translesional synthesis on DNA templates containing 8-oxo-7,8-dihydrodeoxyadenosine. Biochemistry 32, 4615-4621 (1993).

93. Tchou, J. and Grollman, A.P.  Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine.  Mutation Res. 299, 277-287 (1993).

94. Shibutani, S., Margulis, L.A., Geacintov, N.E. and Grollman, A.P.  Translesional synthesis on DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene). Biochemistry 32, 7531-7541 (1993).

95. Grollman, A.P. and Moriya, M.  Mutagenesis by 8-oxoguanine:  An enemy within.  Trends in Genetics 9, 246-249 (1993).

96. Shibutani, S. and Grollman, A.P.  On the mechanism of frameshift (deletion) mutagenesis in vitro.  J. Biol. Chem. 268, 11703-11710 (1993).

97. Moriya, M. and Grollman, A.P.  Mutations of the mutY gene of Escherichia coli enhance the frequency of targeted G:C—T:A transversions induced by a single 8-oxoguanine residue in single-stranded DNA. Molecular Gen. Genet. 239, 72-76 (1993).

98. Grollman, A.P. and Shibutani, S.  Mutagenic specificity of chemical carcinogens as determined by studies with single DNA adducts.  In: DNA Adducts:  Identification and Biological Significance.  Hemminki, K., Dipple, A., Shuker, D., Kadlubar, F.F., Segerback, D. and Bartsch, H. (Eds.), IARC Scientific Publications No. 125, Lyon, France (1993).

99. Tchou, J., Michaels, M.L., Miller, J.H. and Grollman, A.P.  Function of the zinc finger domain in Escherichia coli Fpg protein. J. Biol. Chem. 268, 26738-26744 (1993).

100. Shibutani, S. and Grollman, A.P.  Nucleotide misincorporation of DNA templates containing N-(deoxyguanosin-N²-yl)-2-acetylaminofluorene (dG-N²-AAF).  Chem. Res. Toxicol. 6, 819-824 (1993).

101. Kasai, H., Chung, M.H., Yamamoto, F., Ohtsuka, E., Laval, J., Grollman, A.P. and Nishimura, S.  Formation, inhibition of formation, and repair of oxidative 8-hydroxyguanine DNA damage (review).  Basic Life Sciences 61, 257-262 (1993).

102. Tchou, J., Bodepudi, V., Shibutani, S., Antoshechkin, I., Miller, J., Grollman, A.P. and Johnson, F.  Substrate specificity of Fpg protein:  Recognition and cleavage of oxidatively damaged DNA.  J. Biol. Chem. 269, 15318-15324 (1994).

103. Grollman, A.P., Johnson, F., Tchou, J., and Eisenberg, M.  Recognition and repair of 8-oxoguanine and formamidopyrimidine lesions in DNA.  In:  Annals of New York Academy of Sciences. Vol. 726.  Wallace, S.S., VanHouten, B., and Kow, Y.W. (Eds.), pp. 208-214 (1994).

104. Shibutani, S. and Grollman, A.P.  Miscoding during DNA syntheiss on damaged DNA templates catalyzed by extracts prepared from mammalian cells. Cancer Letters 83, 315-322 (1994).

105. Moriya, M., Zhang, W., Johnson, F. and Grollman, A.P.  Mutagenic potency of exocyclic DNA adducts:  Marked differences between Escherichia coli and simian kidney cells.  Proc. Natl. Acad. Sci. USA 91, 11899-11903 (1994).

106. Zhang, W., Johnson, F., Grollman, A.P. and Shibutani, S.  Miscoding by the exocyclic DNA adducts: 3,N⁴-ethano-2’-deoxycytidine and 3-(2-hydroxyethyl)-2’-deoxyuridine.  Chem. Res. Toxicol. 8, 157-163 (1995).

107. Grollman, A.P.  8-Oxoguanine in DNA:  Its mutagenic properties and repair.  Environ. Mut. Res. Commun. 16, 239-243 (1995).

108. Wilson, D.M. III, Takeshita, M., Grollman, A.P. and Demple, B.  Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA.  J. Biol. Chem. 270, 16002-16007 (1995).

109. Tchou, J. and Grollman, A.P.  The catalytic mechanism of Fpg protein:  Evidence for a Schiff base intermediate and amino-terminus localization of the catalytic site.  J. Biol. Chem. 270, 11671-11677 (1995).

110. Grollman, A.P.  and Takeshita, M.  Miscoding and mutagenic properties of 8-oxoguanine and abasic sites:  Ubiquitious lesions in damaged DNA.  In:  Radiation Damage to DNA:  Structure/Function Relationship of Early Times.  Fuciarelli, A.F. and Zimbrick, J.D. (Eds.), Batelle Press, Columbus, Ohio, pp. 293-304 (1995).

111. Plum, G.E., Grollman, A.P., Johnson, F. and Breslauer, K.J.  Influence of the oxidatively damaged adduct 8-oxodeoxyguanosine on the conformation, energetics, and thermodynamic stability of a DNA duplex.  Biochemistry 34, 16148-16160 (1995).

112. LePage, F., Margot, A., Grollman, A.P., Sarasin, A., and Gentil, A.  Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cells.  Carcinogenesis 16, 2779-2784 (1995).

113. Varaprasad, C.V., Bulychev, N., Grollman, A.P. and Johnson, F.  Synthesis of 8-oxo-7,8-dihydro-6-O-methyl-2’-deoxyguanosine and its use as a probe to study DNA-base excision by mutY enzyme.  Tetrahedron Letters 37, 9-12 (1996).

114. Moriya, M., Spiegel, S., Fernandes, A., Amin, S., Liu, T.-M., Geacintov, N.E. and Grollman, A.P.  Fidelity of translesional synthesis past benzo[a]pyrene diol epoxide-2 deoxyguanosine DNA adducts:  Marked effects of host cell, sequence context, and chirality.  Biochemistry 35, 16646-16651 (1996).

115. Campbell, G., Deng, Y., Glimm, J., Yu, Q., Eisenberg, M. and Grollman, A.P.  Analysis and prediction of protein binding on DNA:  Pattern recognition of hydrogen bonds.  J. Computational Chemistry 17, 1712-1725 (1996).

116. Bulychev, N.V., Varaprasad, C.V., Dorman, G., Miller, J.H., Eisenberg, M., Grollman, A.P. and Johnson, F.  Substrate specificity of E. coli muty protein.  Biochemistry 35, 13147-13156 (1996).

117. Gelfand, C.A., Plum, G.E., Grollman, A.P., Johnson, F., and Breslauer, K.J.  The impact of a bistrand abasic lesion on DNA duplex properties. Biopolymers 38, 439-445 (1996).

118. Korobka, A., Cullinan, D., Cosman, M., Grollman, A.P., Patel, D.J., Eisenberg, M., and de los Santos, C.  Solution structure of an oligodeoxynucleotide duplex containing the exocyclic lesion 3,N⁴-ethenodeoxycytosine opposite deoxyadenine, determined by  NMR spectroscopy and restrained molecular dynamics.  Biochemistry 35, 13310-13318 (1996).

119. Cullinan, D., Korobka, A., Grollman, A.P., Patel, D.J., Eisenberg, M., and de los Santos, C.  NMR solution structure of an oligodeoxynucleotide duplex containing the exocyclic lesion 3,N⁴-ethenodeoxycytosine opposite thymine:  comparison with the duplex containing deoxyadenosine opposite the adduct.  Biochemistry35, 13319-13327 (1996).

120. Greenblatt, M.S., Grollman, A.P., and Harris, C.C.  Deletions and insertions of p53 tumor suppressor gene in human cancers:  Confirmation of the DNA polymerase slippage/misalignment model.  Cancer Res. 56, 2130-2136 (1996).

121. Grollman, A.P. and Takeshita, M.  8-Oxoguanine and bistrand abasic sites in DNA:  Mutagenic potential and repair.  In:  1895-1995 Congress Proceedings Vol. 2.  Hagen, U., Harder, D., Jung, H., and Streffer, C. (Eds.), pp. 316-319 (1996).

122. Shibutani, S., Suzuki, N., Matsumoto, Y. and Grollman, A.P.  Miscoding properties of 3,N⁴-etheno-2’-deoxycytidine in reactions catalyzed by mammalian DNA polymerases.  Biochemistry 35, 14992-14998 (1996).

123. Chen, H., Johnson, F., Grollman, A.P., and Patel, D.J.  Structural studies of the ionizing radiation adduct 7,8-dihydro-8-oxoadenine (A^oxo) positioned opposite thymine in a DNA duplex.  Magnetic Resonance in Chemistry 34, S23-S32 (1996).

124. Karakaya, A., Jaruga, P., Bohr, V.A., Grollman, A.P., and Dizdaroglu, M.  Kinetics of excision of purine lesions from DNA by fpg protein. Nucleic Acids Res. 25, 474-479 (1997).

125. Cullinan, D., Johnson, F., Grollman, A.P., Eisenberg, M. and de los Santos, C.  Solution structure of a DNA duplex containing the exocyclic lesion 3,N⁴-etheno-2’-deoxycytidine opposite 2-deoxyguanosine. Biochemistry 36, 11933-11943 (1997).

126. Zharkov, D., Rieger, R.A., Iden, C.R. and Grollman, A.P.  NH₂-terminal proline acts as a nucleophile in the glycocylase/AP lyase reaction catalyzed by Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg) protein. J. Biol. Chem. 272, 5335-5341 (1997).

127. Shibutani, S., Takeshita, M., and Grollman, A.P.  Translesional synthesis on DNA templates containing a single abasic site:  A mechanistic study of the A rule.  J. Biol. Chem. 272, 13916-13922 (1997).

128. Shibutani, S. and Grollman, A.P.  Molecular mechanisms of mutagenesis by aromatic amines and amides.  Mutation Res. 376, 71-78 (1997).

129. Rosenquist, T., Zharkov, D.O. and Grollman, A.P.  Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.  Proc. Natl. Acad. Sci. USA 94, 7429-7434 (1997).

130. Miller, H. and Grollman, A.P.  Kinetics of DNA polymerase I (Klenow fragment exo^-) activity on damaged DNA templates:  Effect of proximal and distal template damage on DNA synthesis.  Biochemistry 36, 15336-15342 (1997).

131. Gening, L., Takeshita, M., Levine, R.L., Peden, K.W. and Grollman, A.P.  Extrachromosomal unequal homologus recombination and gene conversion in simian kidney cells:  Effects of uv damage.  Mutation Res. 407, 11-24 (1998).

132. Fernandes, A., Liu, T., Amin, S., Geacintov, N.E., Grollman, A.P. and Moriya, M.  Mutagenic potential of stereoisomeric bay region (+)- and (B)-cis-anti-benzo[a]pyrene diol expoxide-N²-deoxyguanosine adducts in Eschericia coli  and simian kidney cells.  Biochemistry 37, 10164-10172 (1998).

133. Shibutani, S., Suzuki, N. and Grollman, A.P.  Mutagenic specificity of acetylaminofluorene-derived DNA adducts in mammalian cells.  Biochemistry 37, 12034-12041 (1998).

134. Zharkov, D.O. and Grollman, A.P.  MutY DNA glycosylase:  base release and intermediate complex formation.  Biochemistry 37, 12384-12394 (1998).

135. Lin, Z., Hung, K.-N., Grollman, A.P. and de los Santos, C. Solution structure of duplex DNA containing an extrahelical abasic site analog determined by NMR spectroscopy and molecular dynamics.  Nucleic Acids Res. 26, 2385-2391 (1998).

136. Gelfand, C.A., Plum, G.E., Grollman, A.P., Johnson, F. and Breslauer, K.J.  The impact of an exocyclic cytosine adduct on DNA duplex properties:  Signficant thermodynamic consequences despite modest lesion-induced structural alterations.  Biochemistry 37, 12507-12512 (1998).

137. Gelfand, C.A., Plum, G.E., Grollman, A.P., Johnson, F. and Breslauer, K.J.  Thermodynamic consequences of an abasic leslion in duplex DNA are strongly dependent on base sequence.  Biochemistry 37, 7321-7327 (1998).

138. Shibutani, S., Fernandes, A., Suzuki, N., Zhou, L., Johnson, F. and Grollman, A.P.  Site-specific mutagenesis of the N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA adduct in mammalian cells.  Z. Lebensm Unters Forsch A 207, 459-463 (1998).

139. Grollman, A.P., Moriya, M., Shibutani, S . and Takeshita, M.  Endogenous DNA damage, mutagenesis, and aging.  In:  Molecular Biology of Aging.  Alfred Benzon Symposium 44.  Bohr, V.A., Clark, B.F.C., Stevnsner, T. (Eds.), Munksgaard, Copenhagen, pp. 191-201 (1999).

140. Tan, X., Suzuki, N., Johnson, F., Grollman, A.P. and Shibutani, S.  Mutagenic properties of the 8-amino-2’-deoxyguanosine DNA adduct in mammalian cells.  Nucleic Acids Res. 27, 2310-2314 (1999).

141. Deng, Y., Glimm, J., Wang, Y., Korobka, A., Eisenberg, M. and Grollman, A.P.  Prediction of protein binding to DNA in the presence of water-mediated hydrogen bonds.  J. Mol. Model. 5, 125-133 (1999).

142. Shibutani, S., Suzuki, N., Terashima, I., Sugarman, S.M., Grollman, A.P. and Pearl, M.L.  Tamoxifen-DNA adducts detected in endometrium obtained from patients treated with tamoxifen.  Chem. Res. Toxicol. 12, 646-653 (1999).

143. Grollman, A.P. and Zharkov, D.O.  Recognition and excision of bases from oxidatively damaged DNA by Fpg, Ogg1, and MutY proteins.  In: Advances in DNA Damage and Repair.  Oxygen Radical Effects, Cellular Protection and Biological Consequences.  Dizdaroglu, M. and Karakaya, A.E. (Eds.), Plenum Publishers, NY, pp. 136-148 (1999).

144. Bonala, R.R., Rieger, R.A., Shibutani, S., Grollman, A.P., Iden, C.R. and Johnson, F.  3,N⁴-Ethano-2’-deoxycytidine:  Chemistry of incorporation into oligomeric DNA and reassessment of miscoding potential.  Nucleic Acids Res. 27, 4725-4733 (1999).

145. Shibutani, S., Fernandes, A., Suzuki, N., Zhou, L., Johnson, F. and Grollman, A.P.  Mutagenesis of the N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA adduct in mammalian cells.  J. Biol. Chem. 274, 27433-27438 (1999).

146. Tan, X., Suzuki, N., Grollman, A.P. and Shibutani, S.  Comparison of the mutagenic properties of 8-oxo-7,8-dihydro-2’-deoxyadenosine and 8-oxo-7,8-dihydro-2’-deoxyguanosine DNA lesions in mammalian cells. Carcinogenesis 20, 2287-2292 (1999).

147. Moriya, M., Pandya, G.A., Johnson, F., and Grollman, A.P. Cellular Response to Exocyclic DNA Adducts. In: Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis. Singer, B. & Bartsch, H. (Eds.), IARC Scientific Publication (Lyon) 150, pp. 263-270 (1999).

148. Miller, H., Prasad, R., Wilson, S.H., Johnson, F., and Grollman, A.P. 8-OxoGTP Incorporation by DNA Polymerase b is Modified by Active-Site Residue Asn279. Biochemistry 39, 1029-1033 (2000).

149. Conlon, K.A., Grollman, A.P., and Berrios, M. Immunolocalization of 8-Oxoguanine in Nutrient-Deprived Mammalian Tissue Culture Cells. J. Histotechnology 23, 37-44 (2000).

150. Rieger, R.A., McTigue, M.M., Kycia, J.H., Gerchman, S.E., Grollman, A.P., and Iden, C.R. Characterization of a Cross-Linked DNA-Endonuclease VIII Repair Complex by Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrometry 11, 505-515 (2000).

151. Shibutani, S., Ravindernath, A., Suzuki, N., Terashima, I., Sugerman, S.M., Grollman, A.P., and Pearl, M.L. Identification of Tamoxifen-DNA Adducts in the Endometrium of Women Treated with Tamoxifen. Carcinogenesis 21, 1461-1467 (2000).

152. Zharkov, D.O., Rosenquist, T.A., Gerchman, S.E., and Grollman, A.P. Substrate Specificity and Reaction Mechanism of Murine 8-Oxoguanine-DNA Glycosylase. J. Biol. Chem. 275, 28607-28617 (2000).

153. Levine, R.L., Yang, I.Y., Hossain, M., Pandya, G.A., Grollman, A.P., and Moriya, M. Mutagenesis Induced by a Single 1,N6-Ethanodeoxyadenosine Adduct in Human Cancer Cells. Cancer Res. 60, 4098-4104 (2000).

154. Zharkov, D.O., Gilboa, R., Yagil, I., Kycia, J.H., Gerchman, S.E., Shoham, G., and Grollman, A.P. A Role for Lysine 142 in the Excision of Adenine from A:G Mispairs by MutY DNA Glycosylase of Escherichia coli. Biochemistry 39, 14768-14778 (2000).

155. Pandya, G.A., Yang, I-Y., Grollman, A.P., and Moriya, M. Escherichia coli Response to a Single DNA Adduct. J. Bacteriology 182, 6598-6604 (2000).

156. Yang, I-Y, Hossain, M., Miller, H., Khullar, S., Johnson, F., Grollman, A.P., and Moriya, M. Responses to the Major Acrolein-Derived Deoxyguanosine Adduct in Escherichia coli. J. Biol. Chem. 276, 9071-9076 (2001).

157. Shibutani, S., Suzuki, N., Tan, X., Johnson, F., and Grollman, A.P. Influence of Flanking Sequence Context on the Mutagenicity of Acetylaminofluorene-Derived DNA Adducts in Mammalian Cells. Biochemistry 40, 3717-3722 (2001).

158. Levine, R.L., Miller, H., Grollman, A.P., Ohashi, E., Ohmori, H., Masutani, C., Hanoaka, F., and Moriya, M. Translesion DNA Synthesis Catalyzed by Human Pol h and Pol k across 1,N⁶- Ethenodeoxyadenosine. J. Biol. Chem. 276, 18717-18721 (2001).

159. Suxuki, N., Ohashi, E., Yahashi, K., Ohnori, H., Grollman, A.P. and Shibutani, S. Translesional synthesis past acetylaminofluorene-derived DNA adducts catalyzed by Human DNA polymerase k and Escherichia coli DNA polymerase IV. Biochemistry 40, 15176-15183 (2001).

160. Zharkov, D.O., Golan, G., Gilboa, R., Fernandes, A.S., Gerchmann, S.E., Kycia, J.H., Rieger, R.A., Grollman, A.P., and Shoham, G. Structural analysis of Escherichia coli endonuclease VIII: its covalent reaction intermediate EMBO J.21, 789-800 (2002).

161. Gilboa, R., Zharkov, D.O., Golan, G., Fernandes, A.S., Gerchman, S.E., Matz, E., Kycia, J.H., Grollman, A.P., Shoham, G. Structure of formamidopyrimidine-DNA glycosylases covalently complexed to DNA. J.Biol.Chem.277, 19811-6 (2002).

162. Zharkov, D.O., Grollman, A.P. Combining Structural and Bioinformatics Methods for the Analysis of Functionally Important Residues in DNA Glycosylases. Free Rad. Biol. Med.,32, 1254-1263 (2002).

163. Tamoxifen-DNA adducts: biomarkers for drug-induced endometrial cancer.

Shibutani, S., Suzuki, N., and Grollman, A.P. In: Biomarkers of Environmentally Associated Disease. Technologies, Concepts and Perspectives. Wilson, S.H., Suk, W.A. (Eds.), CRC Press LLC, pp. 127-137. (2002).

164. Translesion Synthesis by Human DNA Polymerase k on a DNA Template Containing a Single Stereoisomer of dG-(+)- or dG(-)-anti-N²-BPDE (7,8-Dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahdrobenzo[a]pyrene). Suzuki, N., Ohashi, E., Kolganovskiy, A., Geacintov, N.E., Grollman, A.P., Ohmori, H., and Shibutani, S. Biochemistry, 41, 6100-6106. (2002).