MSTP-Associated Research Publications Completed by Trainees

2007:
Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S. (2007). Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 449:346-50.

Zanazzi, G., Matthews, G. (2007). A doubleheader in endocytosis. Neuron. 56(6):939-42.

2006:
Hoos MD, Ahmed M, Smith SO, and Van Nostrand WE (2006). Inhibition of familial cerebral amyloid angiopathy mutant amyloid beta-protein fibril assembly by myelin basic protein. Journal of Biological Chemistry. (Submitted)

Sato T, Kienlen-Campard P, Ahmed M, Liu W, Li H, Elliott JI, Aimoto S, Constantinescu SN, Octave JN, and Smith SO (2006). Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry. 45:5503-16.

Mastrangelo, I.A., Ahmed M., Sato T., Liu W., Wang C., Hough P. and Smith S.O. (2006). High Resolution Atomic Force Microscopy of soluble Abeta42 oligomers. Journal of Molecular Biology. 21:358:106-19.

Bhatt, DH, Fetcho, JR, Zottoli, S (2006). Regeneration in the Adult Spinal Cord. Model Organisms In Regeneration. 1:263-288.

Bhatt, DH, McLean, DL, Hale, ME, Fetcho, JR (2006). In vivo imaging of spinal interneuron recruitment patterns. Neuron. (In press)

Pogoda, HM, Sternheim, N, Bhatt, DH, Fetcho, JR, Talbot, WS (2006). A genetic screen identifies genes essential for axon myelination in zebrafish. Developmental Biology. (In press)

Chung CY, Bien H and Entcheva E (2006). Wavefront incidence angle affects frequency-dependent properties of cardiac cell networks. Am J Physiol – Heart & Circ Physiol. (Submitted)

Bien H, Parikh P and Entcheva E (2006). Lenses and effective spatial resolution in optical mapping. Physics in Medicine and Biology. (In revision)

Entcheva E and Bien H (2005). Mechanical and spatial determinants of cytoskeletal geodesic dome formation in cardiac fibroblasts. (In revision)

Bien H and Entcheva E (2006). Hysteresis in rhythm patterns during electric field stimulation of cardiac tissue. Biophysical Journal. (In submission)

Bien H, Entcheva E, Pertsov A, Mironov S, Vetter F (2006). Spatial frequency content in optical mapping of cardiac cell monolayers. Am J Physiol – Heart & Circ Physiol. 291(3):H484-5.

Bien H, Yin L and Entcheva E (2006). Calcium instabilities in mammalian cardiomyocyte networks. Biophysical Journal. 90(7):2628-40.

Entcheva E and Bien H (2006). Macroscopic optical mapping of excitation in cardiac cell networks with ultra-high spatiotemporal resolution. Progress in Biophysics and Molecular Biology. 92(2):232-57.

Cheng TF, Brzostek S (2006). Ando O, Van Scoy S, Kumar KP, Reich NC. Differential Activation of IFN Regulatory Factor (IRF)-3 and IRF-5 Transcription. J Immunol. 176:7462-7470.

Chabra I and Hearing P. Utilization of a new adenovirus E1-, adeno-associated virus Rep-expressing cell line to readily produce gutted Ad vectors. (Submitted)

Shah, A.B., DiMartino, S.J., Trujillo, G., and Kew, R.R. (2006). Selective inhibition of the C5a chemotactic cofactor function of the vitamin D binding protein by 1,25(OH)2 vitamin D3. Mol. Immunol. 43:1109-15.

Ford, B., Hornak, V., Kleinman, H., and Nassar , N. (2006). Structure of a transient intermediate for GTP hydrolysis by ras. Structure. 14:427-36.

Kleinman, H., Ford, B., Keller, J., Carpino, N., and Nassar, N. (2006). Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1. Acta Crystallograph Sect F Struct. Biol. Cryst Commun. 62:218-20.

Ford B*, Keller J*, Mikhailik A*, Chen Y, Nassar N, and Carpino N. TCR signaling is suppressed by a novel phosphatase activity of Sts-1. *Contributed equally to this work. Submitted to Molecular Cell; revised manuscript under review.

Boehm*, J., Ehrlich*, I., Hsieh*, H., Malinow, M. (2006). Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity. *Contributed equally to this work. Learn Mem. 13(5):562-5.

Hsieh, H., Sato, C., Iwasubo, T., Tomita, T., Sisodia, S, and Malinow, R. AMPA-R Removal Underlies Abeta-induced Synaptic Depression and Dendritic Spine Loss. Neuron. (In review)

Kassem, I.S. and Evinger, C. (2006). Asymmetry of blinking. Invest. Ophthalmol. Vis. Sci. 47:195-201.

LaLonde, M., Janssens, H., Yun, S., Crosby, J., Redina, O., Du, G., Olive, V., Altshuller, Y.M., Gergen, J.P., and Frohman, M.A. Phospholipase D is required for the progression of cellularization in Drosophila and functions by regulating vesicle trafficking. (Submitted)

DiMartino SJ, Trujillo G, McVoy LA, Zhang J, and Kew RR. Upregulation of Vitamin D Binding Protein (Gc-Globulin) Binding Sites During Neutrophil Activation from a Latent Reservoir in Azurophil Granules. (Submitted)

Lin, W., Mittra, E., and Qin, Y.X. (2006). Determination of ultrasound phase velocity in trabecular bone using time dependent phase tracking technique. J. Biomech Eng. 128:24-9.

Mittra, E., S. Akella, and Y-X Qin (2006). The effects of embedding material, loading rate and magnitude, and penetration depth in nanoindentation of trabecular bone. Journal of Biomedical Materials Research A. 79:86-93.

Ocampo CJ, Morrison SA, Dubey SA, Shriver JW, Craddock BP, Steigbigel RT. Immune activation in asymptomatic HIV-1-infected individuals during antiretroviral therapy and treatment cessation. (Submitted)

Alexander I. Sobolevsky, Michael L. Prodromou, Maria V. Yelshansky, and Lonnie P. Wollmuth. Subunit-specific Contribution of NMDA Receptor Subunits to Channel Structure and Gating. (In Preparation)

Loriol C, Dupuy F, Rampal R, Dlugosz MA, Haltiwanger RS, Maftah A, Germot A (2006). Molecular evolution of protein O-fucosyltransferase genes and splice variants. Glycobiology. 16(8):736-47.

Rampal R, Luther K, and Haltiwanger R. Notch Signaling in Normal and Disease States: Possible Therapies Related to Glycosylation. Current Molecular Medicine. (Submitted)

Herbert MR, Russo JP, Yang S, Roohi J, Blaxill M, Kahler SG, Cremer L, Hatchwell E (2006). Autism and environmental genomics. Neurotoxicology. 5:671-84.

Rosen, A.B., Kelly, D.J., Schuldt, A.J.T., Lu, J., Potapova, I.A., Doronin, S.V., Robinson, R.B., Rosen, M.R., Brink, P.B., Gaudette, G.R., and Cohen, I.S. Long term tracking of human mesenchymal stem cells loaded with quantum dots for quantitative in vivo 3-D fluorescence analysis. (Submitted)

Aranda V, Haire T, Nolan ME, Calarco JP, Rosenberg AZ, Fawcett JP, Pawson T, Muthuswamy. SK (2006). Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nature Cell Biology. (In press)

Rosen AB, Kelly DJ, Schuldt AJT, Lu J, Potapova IA, Doronin SV, Robinson RB, Rosen MR, Brink PB, Gaudette GR, Cohen IS. Long term tracking of human mesenchymal stem cells loaded with quantum dots for quantitative in vivo 3-D fluorescence analysis. (Submitted)

Seandel M, Shia J, Linkov I, Maki RG, Antonescu CR, Dupont J. (2006). The activity of sunitinib against gastrointestinal stromal tumor seems to be distinct from its antiangiogenic effects. Clin Cancer Res. 12:6203-4.

Zijlstra, A., Seandel, M., Kupriyanova, T.A., Partridge, J.J., Madsen, M.A., Hahn-Dantona, E.A., Quigley, J.P., and Deryugina, E.I. (2006). Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells. Blood. 107:317-27.

Weston, C., Teressa, G., Gordon, C., Weeks, B., and Prives, J. Agrin and Laminin induced acetylcholine receptor clustering via convergent signaling pathways involving Rho GTPases. (Submitted)

2005:
Jura, N., Archer, H., and Bar-Sagi, D. (2005). Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between. Cell Res. 15:72-7.

Zong X, Bien H, Chung CY, Yin L, Fang D, Chu B, Hsiao BS, and Entcheva E (2005). Electrospun fine-textured scaffolds for heart tissue constructs. Biomaterials. 26(26):5330-5338.

Entcheva E and Bien H (2005). Acoustic micromachining of three-dimensional surfaces for biological applications. Lab on a Chip. 5(2):179-184.

DeJesus, N., Franco, D., Paul, A., Wimmer, E., and Cello, J. (2005). Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence. J. Virol. 79:14235-43.

Ford, B., Skowronek, K., Boykevisch, S., Bar-Sagi, D., and Nassar, N. (2005). Structure of the G60A mutant of Ras: implications for the dominant negative effect. J. Biol Chem. 280:25697-705.

Evinger, C. and Kassem, I.S. (2005). Animal models of benign essential blepharospasm and hemifacial spasm. Animal Models of Movement Disorders (M LeDoux, Ed). Academic Press/Elsevier.

Helfman, D.M., Kim, E.J., Lukanidin, E., and Grigorian, M. (2005). The metastasis associated protein S100A4: role in tumor progression and metastasis. Br. J. Cancer. 92:1955-8.

LaLonde, M.M., Janssens, H., Rosenbaum, E., Choi, S.-Y., Gergen, J.P., Colley, N.J., Stark, W.S., and Frohman, M.A. (2005). Regulation of Phototransduction Responsiveness and Retinal Degeneration by a Phospholipase D-generated Signaling Lipid. J. Cell Biol. 169:471-9.

McVoy, L.A., and R.R. Kew. (2005). CD44 and annexin A2 mediate the C5a chemotactic cofactor function of the vitamin D binding protein. J. Immunol. 175:4754-60.

Mittra, E., Rubin, C., and Qin, Y.X. (2005). Interrelationship of trabecular mechanical and microstructural properties in sheep trabecular bone. J. Biomech. 38:1229-37.

Rampal, R., Li, A.S., Moloney, D.J., Georgiou, S.A., Luther, K.B., Nita-Lazar. A., and Haltiwanger, R.S. (2005). Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats. J. Biol Chem. 280:42454-63.

Rampal, R., Arboleda-Velasquez, J.F., Nita-Lazar, A., Kosik, K.S., and Haltiwanger, R.S. (2005). Highly conserved O-fucose sites have distinct effects on Notch1 function. J. Biol Chem. 280:32133-40.

Arboleda-Velasquez, J.F., Rampal, R., Fung, E., Darland, D.C., Liu, M., Martinez, M.C., Donahue, C.P., Navarro-Gonzalez, M.F., Libby, P., D'Amore, P.A., Aikawa, M., Haltiwanger, R.S., and Kosik, K.S. (2005). CADASIL mutations impair Notch3 glycosylation by Fringe. Hum. Mol. Genet. 14:1631-9.

Saxena, A., Ma, B., Schramm, L., and Hernandez, N. (2005). Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription. Mol. Cell. Biol. 25:9406-18.

Silva, J.M., Li, M.Z., Chang, K., Ge, W., Golding, M.C., Rickles, R.J., Siolas, D., Hu, G., Paddison, P.J., Schlabach, M.R., Sheth, N., Bradshaw, J., Burchard, J., Kulkarni, A., Cavet, G., Sachdanandam, R., McCombie, W.R., Cleary, M.A., Elledge, S.J., and Hannon, G.J. (2005). Second-generation shRNA libraries covering the mouse and human genomes. Nat. Genet. 37:1281-8.

Siolas, D., Lerner, C., Burchard, J., Ge, W., Linsley, P.S., Paddison, P.J., Hannon, G.J., and Cleary, M.A. (2005). Synthetic shRNAs as potent RNAi triggers. Nat. Biotechnol. 23:227-31.

Lee, L.P., Szema, R. (2005). Inspirations from Biological Optics for Advanced Photonic Systems." (Cover article) Science. 310:5751, 1148-1150.

2004:
Auster, A.S. and Joshua-Tor, L. (2004). The DNA-binding Domain of Human Papillomavirus Type 18 E1: Crystal Structure, Dimerization, and DNA Binding. Journal of Biological Chemistry. 279:3733-42.

Fetcho, J.R., and Bhatt, D.H. (2004). Genes and photons: new avenues into the neuronal basis of behavior. Curr. Opin. Neurobiol. 14:707-14. (Review)

Bhatt, D.H., Otto, S.J., Depoister, B., and Fetcho, J.R. (2004). Cyclic AMP-induced repair of zebrafish spinal circuits. Science. 305:254-8.

Fetcho, JR & Bhatt, DH (2004). Genes and photons: new avenues into the neuronal basis of behavior. Current Opinion in Neurobiology. 146:707-714.

Yin L, Bien H and Entcheva E (2004). Scaffold topography alters calcium handling in cultured cardiomyocyte networks. Am J Physiol – Heart & Circ Physiol. 287(3): H1276-H1285.

Entcheva E, Bien H, Yin L, Chung C-Y, Farrell M and Kostov Y (2004). Functional cardiac cell constructs on cellulose-based scaffolding. Biomaterials. 25(26):5753-5762.

Hornbeck PV, Chabra I, Kornhauser JM, Skrzypek E, Zhang B (2004). PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics. 4(6):1551-61.

Rusu, L., Gambhir, A., McLaughlin, S. and Raedler, J. (2004). Fluorescence correlation spectroscopy studies of Peptide and protein binding to phospholipid vesicles. Biophys. J. 87:1044-53.

Gambhir, A., Hangyás-Mihályné, G., Zaitseva, I., Cafiso, D.S., Wang, J., Murray, D., Pentyala, S.N., Smith, S.O., and McLaughlin, S. (2004). Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins. Biophys. J. 86:2188-2207.

Wang, J., Gambhir, A., McLaughlin, S.M., and Murray, D. (2004). A Computational Model for the Electrostatic Sequestration of PI(4,5)P2 by Membrane-Adsorbed Basic Peptides. Biophys J. 86:1969-86.

Janardhan A, Swigut T, Hill B, Myers MP, and Skowronski J (2004). HIV-1 Nef Binds the DOCK2-ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis. PLoS Biol. 2:65-76.

LaLonde, M. and Frohman, M.A. (2004). Phospholipase D. In Encyclopedia of Biological Chemistry. (eds. Lennarz, W. and Lane, M.D.). Academic Press/ Elsevier. 3:306-313.

Manganas L.N. and Trimmer J.S. (2004). Calnexin regulates mammalian Kv1 channel trafficking. Biochemical and Biophysical Research Communications. 322:577-84.

Zijlstra, A., Aimes, R.T., Zhu, D., Regazzoni, K., Kupriyanova, T., Seandel, M., Deryugina, EI., and Quigley, J.P. (2004). Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3). J. Biol Chem. 279:27633-45.

Szema, R., Rastegar, J., and Lee, L. (2004). An artificial compound eye for stereoendoscopy. J. Med. Eng. Technol. 28:117-24.

2003:
Guo, H., Seixas-Silva, J.A. Jr., Epperly, M.W., Gretton, J.E., Shin, D.M., Bar-Sagi, D., Archer, H., and Greenberger, J.S. (2003). Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat. Res. 159:361-70.

Epperly, M.W., H.L. Guo, M. Jefferson, S. Nie, J. Gretton, M. Bernarding, D. Bar-Sagi, H. Archer and J.S. Greenberger. (2003). Cell Phenotype Specific Kinetics of Expression of Intratracheally Injected Manganese Superoxide Dismutase-plasmid/liposomes (MnSOD-PL) during Lung Radioprotective Gene Therapy. Gene Therapy. 10:163-171.

Bhatt, DH, New York State MSTP Researchers Competition, Functional Regeneration in Zebrafish 9/2003.

Bhatt, DH and Fetcho, JR, New York State Spinal Cord Research Awards and Symposium, Functional Regeneration and In vivo imaging 2/2003.

Bien H, Yin L and Entcheva E (2003). Cardiac cell networks on elastic microgrooved scaffolds. IEEE Eng Med Biol. 22(5):108-112.

Entcheva E and Bien H (2003). Tension development and nuclear eccentricity in topographically controlled cardiac syncytium. Biomedical Microdevices. 5(2):163-168.

Newman, GC, Delucia-Deranja, E, Tudorica, A, Hospod, F.E., and Patlak, C.S. (2003). Cerebral blood volume measurements by T*2-weighted MRI and contrast infusion. Magn. Reson. Med. 50:844-55.

Grace, K.S., Bronson, R.A., and Ghebrehiwet, B. (2003). Ligation of the C1q Receptor,gC1qR/p33, Associates with Both the avb3 Integrin and Vitronectin and Causes Protein Phosphorylation. Fertil Steril. 80:S5.

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., and Malinow, R. (2003). APP Processing and Synaptic Function. Neuron. 37(6):925-37.

Indyk, J.A., Chen, Z.-l., Tsirka, S.E., and Strickland, S. (2003). Laminin chain expression suggests that laminin-10 is a major isoform in the mouse hippocampus and is degraded by the tissue plasminogen activator/plasmin protease cascade during excitotoxic injury. Neuroscience. 116:359-71.

Chen, Z.-l., Indyk, J.A., and Strickland, S. (2003). The hippocampal laminin matrix is dynamic and critical for neuronal survival. Molecular Biology of the Cell. 14:2665-2676.

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., and Malinow, R. (2003). APP processing and synaptic function. Neuron. 37:925-37.

Kim, E.J., and Helfman, D. M. (2003). Characterization of the metastasis-associated
protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin. J. Biol Chem. 278:30063-30073.

Suzuki, T., Kwofie, M.A., and Lennarz, W.J. (2003). Ngly1, a mouse gene encoding a deglycosylating enzyme implicated in proteasomal degradation: expression, genomic organization, and chromosomal mapping. Biochem. Biophys. Res. Commun. 304:326-32.

Mittra, E.S., A.J. Singer, D. Bluestein, and J.D. Hollander (2003). Simulated wound irrigation impact pressures. Israeli Journal of Emergency Medicine. 3:9-16.

Pessler, F. and Hernandez, N. (2003). Flexible DNA binding of the BTB/POZ-domain protein FBI-1. J. Biol. Chem. 31:29327-35.

Sturla, L., Rampal, R., Haltiwanger, R.S., Fruscione, F., Etzioni, A., and Tonetti, M. (2003). Differential Terminal Fucosylation of N-linked Glycans Versus Protein O-fucosylation in Leukocyte Adhesion Deficiency Type II (CDG IIc). J. Biol. Chem. 278:26727-26733.

Wang, J., Rogove, A.D., Tsirka A.E. and Tsirka, S.E. (2003). Protective Role of Tuftsin Fragment 1-3 in an Animal Model of Intracerebral Hemorrhage. Annals of Neurology. 54:655-664.

Brian P. Helmke, Amy B. Rosen, and Peter F. Davies (2003). Mapping Mechanical Strain of an Endogenous Cytoskeletal Network in Living Endothelial Cells. Biophys. J. 84:2691-2699.

Weston, C., Gordon, C., Teressa, G., Hod, E., Ren, X.-D., and Prives, J. (2003). Cooperative regulation by Rac and Rho of agrin-induced acetylcholine receptor clustering in muscle cells. J Biol Chem. 278:6450-5.

Weston C., Gordon C, Teressa G, Hod E, Ren XD, and Prives J (2003). Cooperative regulation by Rac and Rho of agrin-induced acetylcholine receptor clustering in muscle cells. J. Biol. Chem. 278:6450-5.

2002:
Epperly, M.W., Sikora, C.A., DeFilippi, S.J., Gretton, J.E., Bar-Sagi, D., Archer, H., Carlos, T., Guo, H., and Greenberger, J.S. (2002). Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy. Biol. Blood Marrow Transplant. 8:175-87.

Archer, H. and D., Bar-Sagi. (2002). Ras and Rac as Activators of Reactive Oxygen Species (ROS). Methods Mol. Biol. 189:67-73.

Chen, G., and Stenlund, A. (2002). Sequential and ordered assembly of E1 initiator complexes on the papillomavirus origin of DNA replication generates progressive structural changes related to melting. Mol. Cell Biol. 22:7712-20.

Tudorica, A., Li, H., Hospod, F.E., DeLucia-Deranja, E., Huang, W., Patlak, C.S., and Newman, G.C. (2002). Cerebral Blood Volume Measurements by Rapid Contrast Infusion and T2*-Weighted Echo Planar MRI. Magn. Reson. Med. 47:1145-1157.

Wang J., Gambhir A., Hangyás-Mihályné G., Murray D., Golebiewska U., and McLaughlin S. (2002). How Phosphatidylinositol 4,5-Bisphosphate Binds to the Basic Effector Domain of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS). J. Biol. Chem. 277:34401-34412.

McLaughlin, S., Wang, J., Gambhir, A., and Murry, D. (2002). PIP2 and Proteins: Interactions, Organization and Information Flow. Annual Rev. of Biophysics Biomolecular Structure. 31:151-75.

Grace, K.S., Bronson, R.A., and Ghebrehiwet, B. (2002). Surface Expression of Complement Receptor gC1q-R/p33 Is Increased on the Plasma Membrane of Human Spermatozoa after Capacitation. Biol. Reprod. 66: 823-9.

Munch, J., Janardhan, A., Stolte, N., Stahl-Hennig, C., Ten Haaft, P., Heeney, J.L., Swigut, T., Kirchhoff, F., and Skowronski, J. (2002). T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques. J. Virol. 76:12360-4.

Evinger, C., Bao, J.B., Powers, A.S., Kassem, I.S., Schicatano, E.J., Henriquez, V.M., and Peshori, K.R. (2002). Dry eye, blinking, and blepharospasm. Mov. Disord. 17:S75-8.

Araya, E., Berthier, C., Kim, E., Yeung, T., Wang, X., and Helfman, D. M. (2002). Regulation of coiled-coil assembly in tropomyosins. J. Struct. Biol. 137:176-183.

Campomanes C.R., Carroll K.I., Manganas L.N., Hershberger M.E., Gong B., Antonucci D.E., Rhodes K.J., and Trimmer J.S. (2002). Kv?Beta Subunit Oxidoreductase Activity and Kv1 Potassium Channel Trafficking. Journal of Biological Chemistry. 277:8298-8305.

Rubin, C., Turner, A.S., Muller, R., Mittra, E., McLeod, K., Lin, W., and Qin, Y.X. (2002). Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. Journal of Bone and Mineral Res. 17:349-57.

Rogove, A.D., Lu, W., and Tsirka S.E. (2002). Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration. Cell Death and Differentiation. 9:801-806.

2001:
Ritter, D.A., Bhatt, D.H., and Fetcho, J.R. (2001). In vivo imaging of zebrafish reveals differences in the spinal networks for escape and swimming movements. J. Neurosci. 21:8956-65.

Bhatt, DH*, Ritter, DA*, Fetcho JR (2001). In vivo imaging of zebrafish reveals differences in the spinal networks for escape and swimming movements. J. Neurosci. 1521: 8956-8965.

Chen, G., and Stenlund, A. (2001). The E1 initiator recognizes multiple overlapping sites in the papillomavirus origin of DNA replication. J. Virol. 75:292-302.

DiMartino, S.J., Shah, A.B., Trujillo, G., and Kew, R.R. (2001). Elastase controls the binding of the vitamin D-binding protein (Gc-globulin) to neutrophils: a potential role in the regulation of C5a co-chemotactic activity. J. Immunol. 166:2688-94.

Singh, N., Talalayeva, Y., Tsiper M., Romanov, V., Dranovsky, A., Colflesh, D., Rudamen, G., Vitek, M.P., Shen, J., Yang, X.D., Goldgaber, D., and Schwarzman, A.L. (2001). The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion. Exp. Cell Res. 263:1-13.

Dranovsky, A., Vincent, I., Gregori L., Schwarzman, A.L., Enghild, J., Strittmatter, W., Davies, P., and Goldgaber, D. (2001). Cdc2 phosphorylated nucleolin demarcates mitotic changes and Alzheimer’s disease pathology. Neurobiol of Aging. 22:517-528.

Suzuki, T., Park, H., Kwofie, M.A., and Lennarz, W.J. (2001). Rad23 provides a link between the Png1 deglycosylating nzyme and the 26 S proteasome in yeast. J. Biol. Chem. 276:21601-7.

Robert L. Levine, Holly Miller, Arthur Grollman, Eiji Ohashi, Haruo Ohmori, Chikahide Masutani, Fumio Hanaoka, and Masaaki Moriya (2001). Translesion DNA synthesis catalyzed by human pol h and pol k across 1,N6-ethenodeoxyadenosine. Journal of Biological Chemistry. 276:18717-18721.

Manganas L.N., Wang Q., Scannevin R.H., Antonucci D.E., Rhodes K.J., and Trimmer J.S. (2001). Identification of a Trafficking Determinant Localized to the Kv1 Potassium Channel Pore. Proceedings of the National Academy of Science. 98:14055-14059.

Manganas L.N., Akhtar S., Antonucci D.E., Campomanes C.R., Oliver Dolly J. and Trimmer J.S. (2001). Episodic Ataxia Type-1 Mutations in the Kv1.1 Potassium Channel Display Distinct Folding and Intracellular Trafficking Properties. Journal of Biological Chemistry. 276:49427-49434.

Seandel, M., Noack-Kunnmann, K., Zhu, D., Aimes, R.T., and Quigley. J.P. (2001). Growth factor-induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen. Blood. 97:2323-32.

2000:
W.S. Asch and N. Schechter. (2000). Plasticin, a Type III Neuronal Intermediate Filament Protein, Assembles as an Obligate Heteropolymer: Implications for Axonal Flexibility. J. Neurochem. 75:1475-1486.

McCaughran, J.A. Jr., Bell, J. III, and Hitzemann, R.J. (2000). Fear-potentiated startle response in mice: genetic analysis of the C57BL/6J and DBA/2J intercross. Pharmacol. Biochem. Behav. 65:301-12.

Enemark, E.J., Chen, G., Vaughn, D.E., Stenlund, A., and Joshua-Tor, L. (2000). Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus. Mol. Cell. 6:149-58.

Gillitzer, E., Chen, G., and Stenlund, A. (2000). Separate domains in E1 and E2 proteins serve architectural and productive roles for cooperative DNA binding. EMBO J. 19:3069-79.

Chen, G., and Stenlund, A. (2000). Two patches of amino acids on the E2 DNA binding domain define the surface for interaction with E1. J. Virol. 74:1506-12.

Carl, S., Iafrate, A.J., Lang, S.M., Stolte, N., Stahl-Hennig, C., Matz-Rensing, K., Fuchs, D., Skowronski, J., and Kirchhoff, F. (2000). Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques. J. Virol. 74:4155-64.

Iafrate, A.J., Carl, S., Bronson, S., Stahl-Hennig, C., Swigut, T., Skowronski, J., and Kirchhoff, F. (2000). Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J. Virol. 74:9836-44. Erratum in: J. Virol . 74:12002.

Swigut, T., Iafrate, A.J., Muench, J., Kirchhoff, F., and Skowronski, J. (2000). Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression. J. Virol. 74:5691-701.

Carl, S., Daniels, R., Iafrate, A.J., Easterbrook, P., Greenough, T.C., Skowronski, J., and Kirchhoff, F. (2000). Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection. J. Infect Dis. 181:132-40.

Robert L. Levine, In-Young Yang, Munfarah Hossain, Gagan A. Pandya, Arthur P. Grollman, and Masaaki Moriya (2000). Mutagenesis induced by a Single 1,N6-Ethenodeoxyadenosine Adduct in Human Cells. Cancer Research. 60:4098-4104.

Tiffany A.F., Manganas L.N., Kim E., Sheng M., and Trimmer J.S. (2000). PSD-95 and SAP-97 Exhibit Distinct Mechanisms for Regulating K+ Channel Surface Expression and Clustering. Journal of Cell Biology. 148:147-157.

Manganas L.N. and Trimmer J.S. (2000). Subunit Composition Determines Kv1 Potassium Channel Surface Expression. Journal of Biological Chemistry. 275:29685-29693.

Melchor JP, McVoy L, and Van Nostrand WE (2000). Charge alterations of E22 enhance the pathogenic properties of amyloid beta-protein. J. Neurochem. 74:2209-2212.

Weston, C.A., Anova, L., Rialas,C., Prives, J.M., and Weeks, B.S. (2000). Laminin-1 activates Cdc42 in the mechanism of laminin-1-mediated neurite outgrowth. Exp. Cell Res. 260:374-8.

Weston, C., Yee, B., Hod, E., and Prives, J. (2000). Agrin-induced acetylcholine receptor clustering is mediated by the small Rho guanine nucleotide exchange factors Rac and Cdc42. J. Cell Biol. 150:205-212.

Rialas, C.M., Nomizu, M., Patterson, M., Kleinman, H.K., Weston, C.A., and Weeks, B.S. (2000). Nitric oxide mediates laminin-induced neurite outgrowth in PC12 cells. Exp. Cell Res. 260:374-378.

1999:
Leake, D , W.S. Asch, Canger, A.K., and Schechter, N. (1999). Gefiltin expression in zebrafish embryos: sequential expression of two neurofilament proteins in retinal ganglion cells. Differentiation. 65:181-189.

McCaughran, J. Jr., Bell, J., and Hitzemann, R. (1999). On the relationships of high-frequency hearing loss and cochlear pathology to the acoustic startle response (ASR) and prepulse inhibition of the ASR in the BXD recombinant inbred series. Behav Genet. 29:21-30.

DiMartino, S.J., and Kew, R.R. (1999). Initial characterization of the vitamin D binding protein (Gc-globulin) binding site on the neutrophil plasma membrane: evidence for a chondroitin sulfate proteoglycan. J. Immunol. 163:2135-42.

Faris S., Wilson D., Barrett H., Dougherty D., Gindi G., Hsiao I.T. (1999). Using a digital anatomical phantom to optimize an imaging system. In Proc. SPIE Medical Imaging. vol. 3659.

Schwarzman, A. L., Singh, N., Tsiper, M., Gregori, L., Dranovsky, A., Vitek M. P., Glabe, C.G., St. George-Hyslop, P., and Goldgaber, D. (1999). Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. Proc. Nat. Acad. Sci. 96:7932-7937.

Kazantsev, A., Preisinger, E., Dranovsky, A., Goldgaber, D., and Housman, D. (1999). Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells. Proc. Nat. Acad. Sci. 96:11404-11409.

Murray D., Arbuzova A., Mihalyne G., Gambhir A., Ben-Tal N., Honig B., and McLaughlin S. (1999). Electrostatic Properties of Membranes Containing Acidic Lipids and Adsorbed Basic Peptides: Theory and Experiment. Biophys. J. 77:3176-3188.

Skowronski, J., Greenberg, M.E., Lock, M., Mariani, R., Salghetti, S., Swigut, T., and Iafrate, A.J. (1999). HIV and SIV Nef modulate signal transduction and protein sorting in T cells. Cold Spring Harb. Symp. Quant. Biol. 64:453-63. ( Review)

Lock, M., Greenberg, M.E., Iafrate, A.J., Swigut, T., Muench , J., Kirchhoff, F., Shohdy, N., and Skowronski, J. (1999). Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis. EMBO J. 18:2722-33.

Carl, S., Iafrate, A.J., Lang, S.M., Stahl-Hennig, C., Kuhn, E.M., Fuchs, D., Matz-Rensign, K., Ten Haaft, P., Heeney, J.L., Skowronski, J., and Kirchhoff, F. (1999). The acidic region and conserved putative protein kinase C phosphorylation site in Nef are important for SIV replication in rhesus macaques. Virology. 257:138-55.

Carl, S., Iafrate, A.J., Skowronski, J., Stahl-Hennig, C., and Kirchhoff, F. (1999). Effect of the attenuating deletion and of sequence alterations evolving in vivo on simian immunodeficiency virus C8-Nef function. J. Virol. 73:2790-7.

Indyk, J.A., Chen, Z.-L., and Strickland, S. (1999). Proteases and degradation of extracellular matrix in neurodegeneration. Fibrinolysis & Proteolysis. 13:64-71.

Chen, Z.-l., Indyk, J.A., Bugge, T.H., Kombrinck, K.W., Degen, J.L, and Strickland, S. (1999). Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes. J. Neuroscience. 19:9813-9820.

Liu, M., Lee, B.H., and Mathews, M.B. (1999). Involvement of RFX1 protein in the regulation of the human proliferating cell nuclear antigen promoter. J. Biol. Chem. 274:15433-39.

Rogove, A.D., Siao C-J, Keyt, B., Strickland, S. and Tsirka, S. E. (1999). Activation of microglia reveals a non-proteolytic cytokine function for tissue plasminogen activator in the central nervous system. Journal of Cell Science. 112:4007-4016.

Venkatesan, C., and Kritzer, M.F. (1999). Perinatal gonadectomy affects corticocortical connections in motor but not visual cortex in adult male rats. J. Comp. Neurol. 415:240-65.

1998:
Alexander, D.S., Sipley, J.D., and Quigley, J.P. (1998). Autoactivation of avian urokinase-type plasminogen activator (uPA). A novel mode of initiation of the uPA/plasmin cascade. J. Biol. Chem. 273:7457-61.

W.S., Asch, D., Leake, A.K., Canger, M., Passini, F., Argenton, and N., Schechter. (1998). Cloning of the Zebrafish Neurofilament Proteins Plasticin and Gefiltin: Increased mRNA Expression in Retinal Ganglion Cells After Optic Nerve Crush. J. Neurochem. 71:20-32.

M.A., Passini, L. Kurtzman, A. K., Canger, W. S., Asch, G. A., Wray, P. A., Raymond, and N. Schechter. (1998). Cloning of Zebrafish vsx1: Expression of a paired-Like homeobox Gene During CNS Development. Dev. Genetics. 23:128-141.

A.K. Canger, M. Passini, W. S. Asch, D. Leake, B. T. Zafonte, E. Glasgow, and N. Schechter. (1998). Restricted Expression of the Neurofilament Protein Plasticin During Zebrafish Development. J. Comp. Neurol. 399:561-572.

Chen, G., and Stenlund, A. (1998). Characterization of the DNA-binding domain of the bovine papillomavirus replication initiator E1. J. Virol. 72:2567-76.

Dougherty D.A., Hsiao I.T., Wang W., and Gindi G.R. (1998). Computerized Biological Brain Phantom for Evaluation of PET and SPECT Reconstruction. IEEE Transactions in Nuclear Sci. 45:1238-43.

Greenberg, M.E., Iafrate, A.J., Skowronski, J. (1998). The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J. 17:2777-89.

Lee, B.H., Liu M, Mathews, M.B. (1998). Regulation of the human proliferating cell nuclear antigen promoter by the adenovirus E1A-associated protein. J. Virol. 72:1138-45.

Gening, L., Takeshita, M., Levine, R.L., Peden, K.W., and Grollman, A.P. (1998). Extrachromosomal unequal homologous recombination and gene conversion in simian kidney cells: effects of UV damage. Mutation Research. 407:11-24.

Pessler, F. and Hernandez, N. (1998). The HIV type 1 inducer of short transcripts activates the synthesis of DRB resistant short transcripts in vitro. J. Biol. Chem. 273:5375-84.

Rogove, A.D. and Tsirka, S.E. (1998). Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus. Current Biology. 8:19-25.

1997:
Sipley, J.D., Alexander D.S., Testa J.E., and Quigley, J.P. (1997). Introduction of an RRHR motif into chicken urokinase-type plasminogen activator (ch-uPA) confers sensitivity to plasminogen activator inhibitor (PAI)-1 and PAI-2 and allows ch-uPA-mediated extracellular matrix degradation to be controlled by PAI-1. Proc. Natl. Acad. Sci. USA. 94:2933-8.

Kew, R.R., Peng, T., DiMartino, S.J., Madhavan, D., Weinman, S.J., Cheng, D., and Prossnitz, E.R. (1997). Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure/function relationships. J. Leukoc. Biol. 61:329-37.

Gindi G., Dougherty D., Hsiao I., and Rangarajan A. (1997). Autoradiographic-based phantoms for emission tomography. In Proc. SPIE Medical Imaging. 3034:403-414.

Lang, S.M., Iafrate, A.J., Stahl-Hennig, C., Kuhn, E.M., Nisslein, T., Kaup, F.J., Haupt, M., Hunsmann, G., Skowronski, J., and Kirchhoff, F. (1997). Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques. Nat. Med. 3:860-5.

Iafrate, A.J., Bronson, S., and Skowronski, J. (1997). Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO J. 16:673-84.

Lee, B.H., and Mathews, M.B. (1997). Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein. Proc. Natl. Acad. Sci. USA. 94:4481-6.

Wreden, C., Verrotti, A.C., Schisa, J.A., Lieberfarb, M.E., and Strickland, S. (1997). Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA. Development. 124:3015-23.

Pessler, F., Pendergrast P.S., and Hernandez, N. (1997). Purification and characterization of FBI-1, a cellular factor that binds to the HIV type 1 inducer of short transcripts. Mol. Cell. Biol. 17:3786-3798

Tsirka, S.E., Rogove, A.D., Bugge, T., Degen, J. and Strickland, S. (1997). An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J. Neuroscience. 17:543-552.

1996:
Alexander, D.S., Aimes, R.T., and Quigley, J.P. (1996). What structure and function of avian plasminogen activator and matrix metalloproteinase-2 reveal about their counterpart mammalian enzymes, their regulation and their role in tumor invasion. Enzyme Protein. 49:38-58. (Review)

Bhatt, DH, Green, BA , (1996). The Molecular Biology of Regeneration in the CNS. Concepts in Neurosurgery: The Molecular Basis of Neurological Disease. 80:111-169.

Dranovsky, A., Oxberry, W., Lyubsky, S., and Goldgaber, D. (1996). APP is associated with mitotic centrosomes and a distinct cytoplasmic network which colocalizes with depolymerized tubulin. Neurobiology of Aging. 17:S196-S196.

Wade, P.R., Chen, J., Kassem, I.S., Blakely, R.D., and Gershon, M.D. (1996). Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J. Neurosci. 16:2352-2364.

Lieberfarb, M.E., Chu, T., Wreden, C., Theurkauf, W., Gergen, J.P., and Strickland, S. (1996). Mutations that perturb poly(A)-dependent maternal mRNA activation block the initiation of development. Development. 122:579-88.

Strickland, S., Gualandris, A., Rogove, A.D. and Tsirka, S. E. (1996). Extracellular proteases in neuronal function and degeneration. CSH Symposia on Quantitative Biology. 61:739-745.

Tsirka, S.E., Rogove, A.D. and Strickland, S. (1996). tPA and neuronal death. Nature. 384:123-124.

1995:
Dranovsky, A., Goldfarb, L., Gajdusek, D.C., and Goldgaber, D. (1995). Apolipoprotein E epsilon 4 allele does not correlate with amyloid plaques in transmissible spongiform encephalopathies. Amyloid: Int. J. Exp. Clin. Invest. 2:36-38.

Labrie, C., Lee, B.H., and Mathews, M.B. (1995). Transcription factors RFX1/EF-C and ATF-1 interact with the adenovirus E1A-responsive element of the human proliferating cell nuclear antigen promoter. Nuc. Acids Res. 23:3732-41.

1994:
Stefansson, S., Aimes, R.T., Seward, N.B., Alexander, D.S., and Quigley, J.P. (1994). Native TIMP-free 70 kDa progelatinase (MMP-2) secreted at elevated levels by RSV transformed fibroblasts. J. Cell. Physiol. 161:419-28.

Salles, F.J., Lieberfarb, M.E., Wreden, C., Gergen, J.P., and Strickland, S. (1994). Coordinate initiation of Drosophila development by regulated polyadenylation of maternal messenger RNAs. Science. 266:1996-9.

1991:
Whitbread, J.A., Sims, M., and Katz, E.R. (1991). Evidence for the presence of a growth factor in Dictyostelium discoideum. Dev Genet. 12:78-81.

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